Is it butyrate safe?
Butyric acid is a metabolite of fibre fermentation in the gut and is considered safe.
In a clinical study with patients with Crohn's disease, taking twice 2 grams per day (4 g) for 8 weeks was well tolerated and considered safe.
Di Sabatino A, Morera R, Ciccociocioppo R, Cazzola P, Gotti S, Tinozzi FP, et al Oral butyrate for mildly to moderately active Crohn’s disease. Aliment Pharmacol Ther 2005;22(9):789-94.
Why take Butycaps during a meal?
Butycaps contains butyrin triglycerides (tributyrin) and lipids for microencapsulation.
It is, therefore, preferable to take Butycaps with a meal to facilitate digestion (production of bile and pancreatic enzymes) and the hydrolysis of triglycerides to fatty acids (butyric acid).
What is the difference between butyrate and probiotics or prebiotics?
Prebiotics are non-digestible substances that serve as a substrate for colon flora. (oligosaccharides and short-chain polysaccharides)
Probiotics are living micro-organisms (bacteria or yeasts).
We speak of intestinal flora (or intestinal microbiota), i.e. all the micro-organisms (archaea, bacteria, eukaryotes) that are found in the digestive tract ( intestine and stomach). The intestinal flora is an excellent example of symbiosis.
The intestinal microbiota produces butyric acid (butyrate) from the fibres. Its production is enhanced by prebiotic agents (soluble fibres).
Does Butycaps contain lactose? Gluten?
Butycaps is lactose-free and gluten-free.
What is the difference between butyrate and glutamine?
Glutamine is an amino acid that acts as an essential nutrient for various organs and tissues, such as muscles, immune cells, and intestinal cells.
It is said to be an essential amino acid under certain conditions: in case of metabolic stress, for example, its consumption is very high by immune system cells. Therefore, in these situations, it is advisable to supplement with glutamine.
Glutamine is also interesting for the intestine because some organs consume glutamine in large quantities when there is metabolic stress. There is a deficit in the intestine, which causes an increase in intestinal permeability.
The fundamental difference is that butyrate is a specific nutrient of the intestine, while glutamine is a nutrient of the intestine and many other organs and tissues.
Therefore, for glutamine to affect the intestine, substantial amounts are required.
On the other hand, butyrate and glutamine are more synergistic than competitors.
Tributyrin (butyrin or tri-butyrate) is a triglyceride of butyrate, a short-chain fatty acid (sometimes called butyric acid or butanoic acid). Butyrin makes up 3 to 4% of the butter. Short-chain fatty acids are produced in the intestine during the digestion of fibre and carbohydrates.
Butyrate is the main source of energy for the gut epithelial cells.