Is it butyrate safe?
Butyric acid is a metabolite of fibre fermentation in the gut and is considered safe.
In a clinical study with patients with Crohn's disease, taking twice 2 grams per day (4g) for 8 weeks was well tolerated and considered safe.
Di Sabatino A, Morera R, Ciccociocioppo R, Cazzola P, Gotti S, Tinozzi FP, et al Oral butyrate for mildly to moderately active Crohn’s disease. Aliment Pharmacol Ther 2005;22(9):789-94.
Why take Butycaps during a meal?
Butycaps contains butyrin triglycerides (fatty acids).
It is, therefore, preferable to take Butycaps Capsules with a meal to facilitate digestion (production of bile and pancreatic enzymes) and the hydrolysis of triglycerides to fatty acids (butyric acid).
What is the difference between butyrate and probiotics or prebiotics?
Prebiotics are non-digestible substances that serve as a substrate for colon flora. (oligosaccharides and short-chain polysaccharides)
Probiotics are living micro-organisms (bacteria or yeasts).
We speak of intestinal flora (or gut microbiota), i.e. all the micro-organisms (archaea, bacteria, eukaryotes) that are found in the digestive tract ( intestine and stomach). The intestinal flora is an excellent example of symbiosis.
The intestinal microbiota produces butyric acid (butyrate) from fibres. Its production is enhanced by prebiotic agents (soluble fibres).
Does Butycaps contain lactose?
Butycaps is lactose-free.
What is the difference between butyrate and glutamine?
Glutamine is an amino acid that acts as an essential nutrient for various organs and tissues, such as muscles, immune cells, and intestinal cells.
It is said to be an essential amino acid under certain conditions: in case of metabolic stress, for example, its consumption is very high by immune system cells. Therefore, in these situations, it is advisable to supplement with glutamine.
Glutamine is also interesting for the intestine because some organs consume glutamine in large quantities when there is metabolic stress. There is a deficit in the intestine, which causes an increase in intestinal permeability.
The fundamental difference is that butyrate is a specific nutrient of the intestine, while glutamine is a nutrient of the intestine and many other organs and tissues.
Therefore, for glutamine to affect the intestine, substantial amounts are required.
On the other hand, butyrate and glutamine are more synergistic than competitors.
In the colon, 90 -95% of the short-chain fatty acids are acetic acid (C2), propionic acid (C3) and butyrate / butyric acid (C4). SCFA are also called "postbiotic" as they are metabolites derived from the microbiota.
Indeed, these fatty acids are produced in the gut during the digestion of fibres and carbohydrates. The colon epithelium consumes almost all butyric acid, the main energy source for colonocytes.
On the other hand, both acetic and propionic acid passe into the blood (portal vein). They are used as precursors in the liver or peripheral tissues for gluconeogenesis and hepatic lipogenesis.